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 THE RED EYE: DIFFERENTIAL DIAGNOSIS

Dany Najjar, MD

Basic principles:

Emergency conditions must be ruled out in any patient presenting with a red eye as they can rapidly progress to blindness. If in doubt, treat the condition as the most severe one.

• Urgent conditions usually present with eye PAIN.

• They also present with CILIARY INJECTION which is engorgement of the deep vessels around the limbus, giving the eye a bluish discoloration, while less urgent conditions present with diffuse injection of superficial vessels.

1. Subconiunctival hemorrhage:

• Very common

• associated with trauma, but also can occur spontaneously in hypertensive patients, after Valsalva or heavy maneuvers, in patients on aspirin or anticoagulation.

• If recurrent: R/O bleeding tendency, R/O occult malignancy.

• Treatment: Reassurance. Treat the underlying condition if present.

2. Blepharoconjunctivitis:

• Conjunctivitis secondary to blepharitis or accompanying it.

• Treat the blepharitis: Lid hygiene and antibiotic ointment.

3. Orbital cellulitis:

• An ophthalmological emergency.

• Orbital edema, erythema, hotness and tenderness. Red eye, decreased vision, decreased ocular motility.

• May be secondary to trauma, insect bite, dacryocystitis, stye, furuncle.

• CT scan to R/O extent of spread.

• Treatment: Admission, IV antibiotics.

• Must be differentiated from preseptal cellulitis, a milder condition in which the infection does not cross the orbital septum. No red eye, no limitation of EOM, no decreased vision. Treatment includes warm compresses, P0 antibiotics.

4. Foreign Body:

• Most common cause of red eye.

• The eyelids must be everted as the foreign body might not be apparent.

• Can cause linear or dot-like scratches on the cornea.

• Treatment: Removal + topical antibiotics.

5. Allergic Conjunctivitis:

• Most important symptom is itching.

• Other symptoms: diffuse injection, foreign body sensation, tearing....

• Slit-lamp findings: giant papillae mainly on the upper eyelids, Tranta’s dots perilimbally, shield ulcer on the cornea.

• Associated with other allergic conditions: allergic rhinitis, asthma.

• Treatment: Cold compresses, lubrication, topical antihistamines (Naphcon A), topical mast cell stabilizers (Alomide) , topical steroids (FML)

6. Viral Conjunctivitis:

• Most common is epidemic keratoconjunctivitis caused by adenovirus.

• Symptoms include: diffuse injection, watery discharge, foreign body sensation.

• History of URTI or contact with persons infected or previous infection in the other eye.

• Exam: preauricular lymph node, follicles in the lower eyelid.

• Treatment: Eye precautions most important, lubrication, cold compresses.

7. Herpes keratoconiunctivitis:

• Might mimic adenoviral conjunctivitis.

• Vesicles on the eyelids may be present.

• Slit lamp exam: typical dendrites on the cornea that uptake fluorescein.

• Treatment: Acyclovir eye ointment.

8. Bacterial conjunctivitis:

• Rapid evolution of symptoms: red eye, thick ropy discharge, eyelid sticking, pain, photophobia.

• Diagnosis: Conjunctival swab cultures

• Treatment: Start topical antibiotics (broad spectrum) pending cultures.

9. Scleritis:

• Hallmark of the disease is severe pain and ciliary injection.

• Must be differentiated from episcleritis (a milder more superficial condition)

• Usually associated with connective tissue diseases.

• Early recognition and treatment is essential since it can lead to melting and perforation.

• Treatment: Systemic steroids + immunosuppressants

10. Episcleritis:

• Inflammation of the episclera, a milder condition than scleritis, usually NOT associated with systemic conditions.

• Localized injection in one quadrant of the eye.

• Treatment: Topical NSAIDs or mild topical steroid.

11. Corneal Ulcer:

• Usually secondary to microtrauma, contact lens wear or can be sterile.

• Eye pain, photophobia, ciliary injection.

• Cultures must be taken and the ulcer is assumed to be infectious, since it can progress rapidly to perforation.

• Treatment: Fortified antibiotics pending results of cultures, cycloplegics.

          12.Acute Angle-closure Glaucoma:

• Occurs in patients with narrow angles often after conditions that cause dilatation of the pupil.

• Severe eye pain, ciliary injection, photophobia, nausea, vomiting, headache.

• Slit lamp exam: Elevated lOP (by tonometry), corneal edema, closed angle on gonioscopy, fixed mid-dilated pupil.

• Treatment: Start immediately P0 Diamox, IV mannitol, topical beta blockers, laser PT, anterior chamber paracentesis.

13. Uveitis:

• Inflammation of the uvea: iris, ciliary body and choroid.

• Anterior uveitis: iritis

• Intermediate : iridocyclitis

• Posterior : Choroiditis, retinitis, chorioretinitis.

• Associated with CT diseases, inflammatory bowel disease.

• Symptoms: eye pain, photophobia, decreased vision.

• Slit-lamp exam: ciliary injection, anterior chamber reaction (flare and cells), vitreous cells in posterior uveitis, keratic precipitates, Koeppe nodules and Busacca nodules, sheathing of BV in retinitis.

• Can lead to blindness if not properly treated.

• Recurrent episodes of uveitis need systemic investigation for an underlying disease: CBC, ESR, U/A, CXR, Calcium, ACE level, ANA, RA latex, VDRL, PPD.

• Fundus exam is mandatory in all cases to RIO posterior uveitis.

• Treatment:

Anterior uveitis: topical steroids, cycloplegics. Intermediate/posterior uveitis: topical + systemic steroids. Steroid ocular injections in some cases, cycloplegics.

14. Endophthalmitis:1

• Inflammation of all the layers of the eye.

• Is the most severe ophthalmological emergency.

• Severe eye pain, ciliary injection, anterior chamber reaction, vitreous cells.

• Can occur post-op and is the most feared condition.

• Treatment: Might need enucleation if topical, systemic (IV), and intraocular injections of antibiotics fail.


        


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